Make sure you can inflict Weaken on the enemies. Bring in the Sealed Stone Life
Spirit's Protection with you. As for the Weapons, equip the ones that enable
Soul Crash or ones that enables 3 Attacks. If you have Dragon Slayer Modified,
Bahamut Tear, Splitting Sword Farewell and Valkyrie Favor, that will be better.
As for skills, have Toughness, First Aid...etc As for Accessories, make sure
you equip the Heal Ring or the Metabolizer. BTW, combine Life Spirit's
Protection, First Aid and Metabolizer/Heal Ring, you will be nearly invincible.
If you have Aluze, use his Increible Ache. That can inflict Weaken. If you can
not beat Homunculus Silmeria in one turn, try to Weaken her. As for Homunculus
Lezard, just keep up the healings and few Soul Crushes should finish him off.